Impairment of neutrophil reactivity to elastin peptides in COPD.

RATIONALE Neutrophils play an important role in the inflammatory process associated with chronic obstructive pulmonary disease (COPD). Lung-infiltrating neutrophils secrete elastinolytic proteases that participate in elastin breakdown and the formation of elastin peptides (EPs). OBJECTIVES We hypothesized that circulating neutrophil-associated immune… (More)