Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.

  title={Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.},
  author={Abdul Hakkim and Barbara G F{\"u}rnrohr and Kerstin Amann and Britta Laube and Ulrike Abu Abed and V Brinkmann and Martin Herrmann and Reinhard Edmund Voll and Arturo Zychlinsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 21},
Systemic lupus erythematosus (SLE) is an autoimmune disease in which patients develop autoantibodies to DNA, histones, and often to neutrophil proteins. These form immune complexes that are pathogenic and may cause lupus nephritis. In SLE patients, infections can initiate flares and are a major cause of mortality. Neutrophils respond to infections and release extracellular traps (NETs), which are antimicrobial and are made of DNA, histones, and neutrophil proteins. The timely removal of NETs… CONTINUE READING
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Incidence and risk factors of infection in a single cohort of 110 adults with systemic lupus erythematosus

  • SJ Jeong
  • Scand J Infect Dis 41:268–274
  • 2009
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