Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis

@article{Kikuchi2002ImpairmentOM,
  title={Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis},
  author={H. Kikuchi and A. Furuta and Ken-ichi Nishioka and S. Suzuki and Y. Nakabeppu and T. Iwaki},
  journal={Acta Neuropathologica},
  year={2002},
  volume={103},
  pages={408-414}
}
  • H. Kikuchi, A. Furuta, +3 authors T. Iwaki
  • Published 2002
  • Biology, Medicine
  • Acta Neuropathologica
  • Abstract. Oxidative stress plays an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). In the present study, we investigated the expression of two major human enzymes that prevent errors caused by 8-oxoguanine (8-oxoG), a mitochondrial form of 8-oxoG DNA glycosylase (hOGG1) and oxidized purine nucleoside triphosphatase (hMTH1). We also investigated the relationship between their expression and the 8-oxoG accumulation observed in the large motor neurons of the lumbar… CONTINUE READING
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    References

    SHOWING 1-10 OF 41 REFERENCES
    Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice.
    • 101
    Oxidative Stress and Motor Neurone Disease
    • 206
    Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons.
    • 572
    RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease
    • 673
    • PDF