Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1.

@article{Inoue2012ImpairmentOI,
  title={Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1.},
  author={Kazuaki Inoue and Kyoko Tsukiyama-Kohara and Chiho Matsuda and M. Yoneyama and Takashi Fujita and Shusuke Kuge and M. Yoshiba and Michinori Kohara},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={428 4},
  pages={494-9}
}
Interferon regulatory factor-3 (IRF-3), a key transcriptional factor in the type I interferon system, is frequently impaired by hepatitis C virus (HCV), in order to establish persistent infection. However, the exact mechanism by which the virus establishes persistent infection has not been fully understood yet. The present study aimed to investigate the… CONTINUE READING