Impairment of human ether-à-go-go-related gene (HERG) K+ channel function by hypoglycemia and hyperglycemia. Similar phenotypes but different mechanisms.

@article{Zhang2003ImpairmentOH,
  title={Impairment of human ether-{\`a}-go-go-related gene (HERG) K+ channel function by hypoglycemia and hyperglycemia. Similar phenotypes but different mechanisms.},
  author={Yiqiang Zhang and Hong Peng Han and Jingxiong Wang and Huizhen Wang and Baofeng Yang and Zhiguo Wang},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 12},
  pages={10417-26}
}
Hyperglycemia and hypoglycemia both can cause prolongation of the Q-T interval and ventricular arrhythmias. Here we studied modulation of human ether-à-go-go-related gene (HERG) K(+) channel, the major molecular component of delayed rectifier K(+) current responsible for cardiac repolarization, by glucose in HEK293 cells using whole-cell patch clamp techniques. We found that both hyperglycemia (extracellular glucose concentration [Glu](o) = 10 or 20 mm) and hypoglycemia ([Glu](o) = 2.5, 1, or 0… CONTINUE READING

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