Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice.

Abstract

It has been demonstrated that the function of mammalian clock gene transcripts is controlled by the binding of heme in vitro. To examine the effects of heme on biological rhythms in vivo, we measured locomotor activity (LA) and core body temperature (T(b)) in a mouse model of porphyria with impaired heme biosynthesis by feeding mice a griseofulvin (GF… (More)
DOI: 10.1152/ajpregu.00019.2011

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