Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.

@article{Iliff2014ImpairmentOG,
  title={Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.},
  author={Jeffrey J Iliff and Michael Chen and Benjamin A. Plog and Douglas M Zeppenfeld and Melissa Soltero and Lijun Yang and Itender Singh and R. Travis Deane and Maiken Nedergaard},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 49},
  pages={
          16180-93
        }
}
Traumatic brain injury (TBI) is an established risk factor for the early development of dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits neurofibrillary tangles comprised of aggregates of the protein tau. We have recently defined a brain-wide network of paravascular channels, termed the "glymphatic" pathway, along which CSF moves into and through the brain parenchyma, facilitating the clearance of interstitial solutes, including amyloid-β, from the brain… CONTINUE READING

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