Impairment of gamma carboxylation of circulating osteocalcin (bone gla protein) in elderly women

  title={Impairment of gamma carboxylation of circulating osteocalcin (bone gla protein) in elderly women},
  author={Luisa Plantalech and Marc Guillaumont and Philippe Vergnaud and M. Leclercq and Pierre Dominique Delmas},
  journal={Journal of Bone and Mineral Research},
Osteocalcin, also called bone gla protein, is a unique noncollagenous protein of the extracellular matrix of bone that circulates in blood. Oseteocalcin contains three residues of the vitamin K‐dependent γ‐carboxyglutamic acid (gla) responsible for the affinity of osteocalcin for bone mineral. In animals treated with the vitamin K antagonist warfarin, the osteocalcin content of bone is markedly reduced and the fraction of osteocalcin released into the circulation is increased. Most studies have… 

Editorial: Serum Undercarboxylated Osteocalcin and the Risk of Hip Fracture

  • Biology, Medicine
  • 1997
Vergnaud et al. (10) supports previous investigations that have suggested that measurements of bone markers are useful predictors of fracture risk, and addresses the relevance of vitamin K deficiency to possible abnormalities in osteocalcin function.

Serum Osteocalcin in Postmenopausal Women-A Pilot Study

  • Medicine, Biology
  • 2022
Bone turnover gets higher as the years progress among the post menopausal state which is reflected in ALP, Uc-OC and C-OC values, which were higher in post-menopausal < 5years than those in > 5 years.

A Preliminary Study of Serum Osteocalcin in Postmenopausal Women

Bone turnover gets higher as the years progress among the post-menopausal state which is reflected in ALP, Uc-OC and C-OC, and more insight into this state is required to be studied with larger sample size.

Vitamin K and bone health

  • S. Bügel
  • Medicine, Biology
    Proceedings of the Nutrition Society
  • 2003
Recent data suggest that the requirement for vitamin K in relation to bone health might be higher, compared with the current dietary recommendation, based on saturation of the coagulation system.

Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women

  • T. YasuiY. Miyatani M. Irahara
  • Medicine
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2006
Combined treatment with vitamin K2 and vitamin D3 may be effective for sustaining BMD in early postmenopausal women whose bone turnovers are highly activated.

Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women

The data suggest that ucOC level may be an interesting marker in the investigation of bone status in the elderly, and multiple regression showed that uCOC has the highest predictive value for BMD when including age and body weight in the equation.

Undercarboxylated osteocalcin and development of a method to determine vitamin K status.

The effectiveness of undercarboxylated osteocalcin as a sensitive measure of vitamin K nutritional status was established when concentrations dropped to 17% +/- 14% below baseline with 2 days of repletion with vitamin K1, 5 mg/day, during which prothrombin times did not leave the normal range.

Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin.

If submaximal gamma-carboxylation is related to the prevention of fracture or bone mineral loss, circulating vitamin K concentrations in elderly people should be kept higher than those in young people.

Serum concentration of undercarboxylated osteocalcin and the risk of osteoporosis in thai elderly women.

It was concluded that vitamin K deficiency is one of the risks of osteoporosis with high prevalence in the Thai elderly especially urbanized ones, the supplement of vitamin K should be recommended in Thai osteopootic patients especially the urbanized elderly.



The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion.

The serum immunoreactive osteocalcin level may vary with vitamin K status, and this variance should be taken into consideration if osteomiccin is used as a marker for osteoblast activity.

Impaired carboxylation of osteocalcin in warfarin-treated patients.

Osteocalcin carboxylation in humans is a vitamin K-dependent process and that circulating osteocalcin is structurally altered by warfarin administration, which has pathophysiological implications for the fetalwarfarin embryopathy syndrome, bone disease associated with chronic liver diseases, and possibly for osteoporosis.

Reduced Axial Bone Mineral Content in Patients Taking an Oral Anticoagulant

Osteocalcin serum levels were comparable between the two groups; bone density values measured at appendicular bone were significantly lower in patients taking acenocoumarol, and no significant correlation was found between duration of treatment and bone density.

Decreased serum osteocalcin levels in phenprocoumon-treated patients.

It is concluded that OC carboxylation is impaired in patients receiving oral anticoagulant therapy, which might result from decreased bone formation, although these patients do not have symptoms of bone disease.

Age and menopause-related changes in indices of bone turnover.

Urinary hydroxyproline/creatinine, but not serum osteocalcin or urinary calcium/Creatinine excretion, was a significant predictor of bone mineral density at the lumbar spine and the femoral neck independent of age, consistent with the hypothesis that age-related bone loss after the menopause occurs in the presence of initially increased but subsequently decreasing bone turnover with maintenance of a relative excess of bone resorption.

Plasma BGP: an indicator of spontaneous bone loss and of the effect of oestrogen treatment in postmenopausal women

It is concluded that serial determinations of plasma BGP are useful for determination of the effect of oestrogen therapy in groups of patients, and that plasma B GP measured at the time of the menopause indicates what the rate of bone loss will be.

Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis.

It is found that the circulating levels of vitamin K1 in osteoporotic patients (who had sustained either spinal crush-fractures or fractures of the neck of the femur) were significantly lower than those of age-matched control subjects.