• Medicine
• Published in Contraception 1990
• DOI:10.1016/0010-7824(90)90043-U

Impairment of fertility of male rats with prazosin.

@article{Ratnasooriya1990ImpairmentOF,
  title={Impairment of fertility of male rats with prazosin.},
  author={W. D. Ratnasooriya and Roger M. Wadsworth},
  journal={Contraception},
  year={1990},
  volume={41 4},
  pages={
          441-7
        }
}

• W. D. Ratnasooriya, Roger M. Wadsworth

This study examines the effects of subcutaneous injections of the alpha-adrenoceptor antagonist prazosin on the fertility of male rats. Twice daily administration of prazosin (total 1.4 mg/kg body weight) caused an impairment of fertility (number of implants reduced from 8.4 +/- 0.6 to 1.8 +/- 1.0). This effect was produced no later than 7h after administration of prazosin (assuming mating occurs between 22.30 and 1.30) and was reversible. The treatment severely reduced the vaginal sperm count… CONTINUE READING

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