Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis.

@article{Sasaki1996ImpairmentOF,
  title={Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis.},
  author={Shoichi Sasaki and M. Iwata},
  journal={Neurology},
  year={1996},
  volume={47 2},
  pages={535-40}
}
We studied the possible impairment of fast axonal transport in patients with amyotrophic lateral sclerosis (ALS) to gain some insight into the pathogenesis of the disease. We carried out an ultrastructural investigation of the proximal axons (axon hillock and initial segment) of the anterior horn neurons on samples from 11 ALS patients; specimens from 12 age-matched individuals who died of nonneurological diseases served as controls. Eighty-seven proximal axons that emanated directly from… CONTINUE READING
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