Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea.

@article{Kato2000ImpairmentOE,
  title={Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea.},
  author={Motoshi Kato and P Roberts-Thomson and Bradley G. Phillips and William Geoffrey Haynes and Mikolaj Winnicki and Valentina Accurso and V. K. Somers},
  journal={Circulation},
  year={2000},
  volume={102 21},
  pages={2607-10}
}
BACKGROUND Patients with obstructive sleep apnea (OSA) experience repetitive episodic hypoxemia with consequent sympathetic activation and marked blood pressure surges, each of which may impair endothelial function. We tested the hypothesis that patients with OSA have impaired endothelium-dependent vasodilation, even in the absence of overt cardiovascular disease. METHODS AND RESULTS We studied 8 patients with OSA (age 44+/-4 years) and 9 obese control subjects (age 48+/-3 years). Patients… CONTINUE READING

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