Impairment of endothelium-dependent relaxation of rabbit aortas by cigarette smoke extract--role of free radicals and attenuation by captopril.

@article{Ota1997ImpairmentOE,
  title={Impairment of endothelium-dependent relaxation of rabbit aortas by cigarette smoke extract--role of free radicals and attenuation by captopril.},
  author={Yoshihide Ota and Kiyotaka Kugiyama and Seigo Sugiyama and Masamichi Ohgushi and Takeshi Matsumura and Hiroshi Doi and Nobuhiko Ogata and Hideki Oka and Hirofumi Yasue},
  journal={Atherosclerosis},
  year={1997},
  volume={131 2},
  pages={195-202}
}
The aim of this study was to examine the effects of the water soluble component of cigarette smoke extract (CSE) on endothelium-dependent relaxation (EDR) of isolated rabbit aortas. The incubation with CSE was found to inhibit EDR in a dose-dependent manner. Co-incubation of the aortic strips with superoxide dismutase (SOD), N-acetylcysteine, glutathione or dimethyl sulfoxide (DMSO), free radical scavengers, attenuated the CSE-induced inhibition of the arterial relaxation. Co-incubation of the… CONTINUE READING
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