Impairment of endothelium-dependent relaxation by diesel exhaust particles in rat thoracic aorta.

@article{Ikeda1995ImpairmentOE,
  title={Impairment of endothelium-dependent relaxation by diesel exhaust particles in rat thoracic aorta.},
  author={M Ikeda and Mamoru Suzuki and Kazuhiro Watarai and Masaru Sagai and Takako Tomita},
  journal={Japanese journal of pharmacology},
  year={1995},
  volume={68 2},
  pages={183-9}
}
Nitric oxide released from vascular endothelium plays important regulatory roles in cardiovascular and pulmonary systems. Epidemiological studies suggest that diesel exhaust particles (DEP) seem to be one of the causative factors responsible for the recent increase in pulmonary diseases. To clarify the pathogenic mechanism, the effects of DEP on vascular endothelial functions were investigated in terms of endothelium-dependent relaxation. Ring preparations of rat thoracic aorta were… CONTINUE READING