Impairment of dentate gyrus neuronal progenitor cell differentiation in a mouse model of temporal lobe epilepsy.

@article{Ledergerber2006ImpairmentOD,
  title={Impairment of dentate gyrus neuronal progenitor cell differentiation in a mouse model of temporal lobe epilepsy.},
  author={Debora A Ledergerber and J. -M. Fritschy and Jason E. Kralic},
  journal={Experimental neurology},
  year={2006},
  volume={199 1},
  pages={130-42}
}
Unilateral intrahippocampal injection of kainic acid (KA) in adult mice induces an epileptic focus replicating major histopathological features of temporal lobe epilepsy (TLE). In this model, neurogenesis is impaired in the lesioned dentate gyrus, although cell proliferation transiently is increased bilaterally in the subgranular zone (SGZ). To investigate further the relationship between epileptogenesis and neurogenesis, we compared the differentiation of cells born shortly before and after KA… CONTINUE READING

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