Impairment of dendritic cell functionality and steady-state number in obese mice.

@article{Macia2006ImpairmentOD,
  title={Impairment of dendritic cell functionality and steady-state number in obese mice.},
  author={Laurence Macia and Myriam Delacre and Georges Abboud and T. S. Ouk and Anne Delanoye and Claudie Verwaerde and Pasquine Saule and Isabelle Wolowczuk},
  journal={Journal of immunology},
  year={2006},
  volume={177 9},
  pages={5997-6006}
}
There is a finely tuned interplay between immune and neuroendocrine systems. Metabolic disturbances like obesity will have serious consequences on immunity both at the cellular and at the cytokine expression levels. Our in vivo results confirm the immune deficiency of ob/ob mice, leptin deficient and massively obese, characterized by a reduced Ag-specific T cell proliferation after keyhole limpet hemocyanin immunization. In this report, we show that dendritic cells (DCs), major APCs involved in… CONTINUE READING