Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.

@article{Urbaska1997ImpairmentOB,
  title={Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.},
  author={Ewa M. Urbańska and Tomasz Kocki and Tomasz Saran and Zdzisz. xllaw Kleinrok and Waldemar A Turski},
  journal={Neuroreport},
  year={1997},
  volume={8 16},
  pages={
          3501-5
        }
}
The role of glutamatergic mechanisms in kynurenic acid (KYNA) production was evaluated in vitro. The selective ionotropic agonists NMDA, kainate and AMPA did not affect KYNA synthesis. Agonists of metabotropic (mGLU) and ionotropic receptors: quisqualate, L-glutamate and L-aspartate as well as agonists of mGLU receptors: (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (t-ACPD) and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) diminished KYNA production with different potency. None of the… CONTINUE READING
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