Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability.

@article{Bharath2014ImpairmentOA,
  title={Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability.},
  author={Leena P. Bharath and Robert A. Mueller and Youyou Li and T. Du A. W. Ruan and David C. Kunz and Rebekah Goodrich and Tyler Mills and Lance Deeter and Ashot Sargsyan and Pon Velayutham Anandh Babu and Timothy E. Graham and J. David Symons},
  journal={Canadian journal of physiology and pharmacology},
  year={2014},
  volume={92 7},
  pages={605-12}
}
Autophagy is a lysosomal catabolic process by which cells degrade or recycle their contents to maintain cellular homeostasis, adapt to stress, and respond to disease. Impairment of autophagy in endothelial cells studied under static conditions results in oxidant stress and impaired nitric oxide (NO) bioavailability. We tested the hypothesis that vascular autophagy is also important for induction of NO production caused by exposure of endothelial cells to shear stress (i.e., 3 h × ≈20 dyn/cm(2… CONTINUE READING
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