Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

@article{Saadoun2005ImpairmentOA,
  title={Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption},
  author={Samira Saadoun and Marios C Papadopoulos and Mariko Hara-chikuma and Alan S Verkman},
  journal={Nature},
  year={2005},
  volume={434},
  pages={786-792}
}
Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability1,2,3. The role of AQP1 in endothelial cell function is unknown. Here we show remarkably impaired tumour growth in AQP1-null mice after subcutaneous or intracranial tumour cell implantation, with reduced tumour vascularity and extensive necrosis. A new mechanism for the impaired angiogenesis was established from cell culture studies. Although adhesion and… CONTINUE READING
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