Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion.

@article{Yukawa2014ImpairmentOA,
  title={Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion.},
  author={Yoshiyuki Yukawa and Shinya Ohashi and Yusuke Amanuma and Yukie Nakai and Mihoko Tsurumaki and Osamu Kikuchi and Shin'ichi Miyamoto and Tsunehiro Oyama and Toshihiro Kawamoto and Tsutomu Chiba and Tomonari Matsuda and Manabu Muto},
  journal={American journal of cancer research},
  year={2014},
  volume={4 3},
  pages={279-84}
}
Ethanol and its metabolite, acetaldehyde, are the definite carcinogens for esophageal squamous cell carcinoma (ESCC), and reduced catalytic activity of aldehyde dehydrogenase 2 (ALDH2), which detoxifies acetaldehyde, increases the risk for ESCC. However, it remains unknown whether the ALDH2 genotype influences the level of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion. In the present study, we administered ethanol orally or intraperitoneally to Aldh2-knockout and… CONTINUE READING
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