Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines.

@article{Dangwal2015ImpairmentOW,
  title={Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines.},
  author={Seema Dangwal and Bernd Stratmann and Claudia Bang and Johan Matthes Lorenzen and Regalla Kumarswamy and Jan Fiedler and Christine S. Falk and Claus Juergen Scholz and Thomas Thum and Diethelm Tschoepe},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 6},
  pages={
          1480-8
        }
}
OBJECTIVE MicroRNAs (miRNA/miR) are stably present in body fluids and are increasingly explored as disease biomarkers. Here, we investigated influence of impaired wound healing on the plasma miRNA signature and their functional importance in patients with type 2 diabetes mellitus. APPROACH AND RESULTS miRNA array profiling identified 41 miRNAs significantly deregulated in diabetic controls when compared with patients with diabetes mellitus-associated peripheral arterial disease and chronic… CONTINUE READING
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