Impairment of JCV-specific T-cell response by corticotherapy: effect on PML-IRIS management?

@article{Antoniol2012ImpairmentOJ,
  title={Impairment of JCV-specific T-cell response by corticotherapy: effect on PML-IRIS management?},
  author={Caroline Antoniol and Samantha Jilek and Myriam Schluep and No{\"e}lle Mercier and Mathieu Canales and G{\'e}raldine Le Goff and Claudia Campiche and Giuseppe Pantaleo and Renaud A. Du Pasquier},
  journal={Neurology},
  year={2012},
  volume={79 23},
  pages={
          2258-64
        }
}
OBJECTIVE To investigate the impact of corticosteroids (CS) on the viral-specific T-cell response, in particular the JC virus (JCV)-specific one, in an attempt to determine the optimal timing of CS in the management of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). METHODS A blood draw was performed before and 7 days after the administration of IV CS to 24 patients with relapsing multiple sclerosis (MS). The phenotypic pattern of T cells was… CONTINUE READING
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