Impairment of Gastric Ulcer Healing by Alendronate, a Nitrogen-Containing Bisphosphonate, in Rats

Abstract

Bisphosphonates such as alendronate have been developed as antiresorptive agents capable of treating diseases related to bone remodeling. In the present study, we examined the effect of alendronate on the healing of acetic acid-induced gastric ulcers in rats and investigated the mechanism involved in this action both in vivo and in vitro using the rat… (More)
DOI: 10.1007/s10620-007-9769-5

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