Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.

@article{Meyenn2016ImpairmentOD,
  title={Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.},
  author={Ferdinand von Meyenn and Mario Iurlaro and Ehsan Habibi and Ning Qing Liu and Ali Salehzadeh-Yazdi and F{\'a}tima Santos and Edoardo Petrini and In{\^e}s Milagre and Miao Yu and Zhenqing Xie and Leonie I. Kroeze and Tatyana B. Nesterova and Joop H Jansen and Hehuang Xie and Chuan He and Wolf Reik and Hendrik G. Stunnenberg},
  journal={Molecular cell},
  year={2016},
  volume={62 6},
  pages={
          848-861
        }
}
Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hypomethylated ones (serum-to-2i) is a valuable model system for epigenetic reprogramming. We present a mathematical model, which accurately predicts global DNA demethylation kinetics. Experimentally, we show that the main drivers of global demethylation are neither active mechanisms (Aicda, Tdg, and Tet1-3) nor… CONTINUE READING

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