Impairment of Cerebrovascular Reactivity by Methionine-Induced Hyperhomocysteinemia and Amelioration by Quinapril Treatment

@article{Chao2000ImpairmentOC,
  title={Impairment of Cerebrovascular Reactivity by Methionine-Induced Hyperhomocysteinemia and Amelioration by Quinapril Treatment},
  author={C. Chao and Y. Lee},
  journal={Stroke: Journal of the American Heart Association},
  year={2000},
  volume={31},
  pages={2907-2911}
}
  • C. Chao, Y. Lee
  • Published 2000
  • Medicine
  • Stroke: Journal of the American Heart Association
  • Background and Purpose Human studies have shown that methionine-induced hyperhomocysteinemia impairs brachial artery endothelial function via decreasing nitric oxide activity. However, the effect of homocysteine on cerebrovascular reactivity (CVR), which has been reported to be nitric oxide related in experimental and animal studies, remains unclear in humans. Inhibition of angiotensin-converting enzyme may improve nitric oxide–mediated cerebral as well as peripheral endothelial function. The… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Superoxide-dependent cerebrovascular effects of homocysteine.
    • 65
    • PDF
    Impaired cerebral vasoreactivity and risk of stroke in patients with asymptomatic carotid artery stenosis.
    • 488
    • PDF