Impairment of CD4+ T cell polarization by dengue virus-infected dendritic cells.

@article{Chase2011ImpairmentOC,
  title={Impairment of CD4+ T cell polarization by dengue virus-infected dendritic cells.},
  author={Amanda J. Chase and Freddy A. Medina and Jorge Luis Mu{\~n}oz-Jord{\'a}n},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={203 12},
  pages={1763-74}
}
BACKGROUND The production of type I interferon alpha/beta (IFN-α/β) is crucial to viral clearance during dengue virus (DENV) infection; however, in vitro-infected dendritic cells (DCs) exhibit a decreased capacity to respond to IFN-α/β stimulation, and antigen-presenting cells (APCs) isolated from patients with acute DENV infection exhibit defects in T cell priming. METHODS In order to ascertain the stimulatory capacity of primary human monocyte-derived DCs infected with wild-type DENV… CONTINUE READING

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