Impairment in Workers With Isocyanate-Induced Occupational Asthma and Removed From Exposure in the Province of Québec Between 1985 and 2002

@article{Labrecque2006ImpairmentIW,
  title={Impairment in Workers With Isocyanate-Induced Occupational Asthma and Removed From Exposure in the Province of Qu{\'e}bec Between 1985 and 2002},
  author={Manon M. Labrecque and Elyess Khemici and Andr{\'e} Cartier and J-L. Malo and J Turcot},
  journal={Journal of Occupational and Environmental Medicine},
  year={2006},
  volume={48},
  pages={1093-1098}
}
Objective: The objective of this project was to assess both the outcome for patients diagnosed with proven isocyanate-induced occupational asthma (IIOA) by specific inhalation challenge (SIC) and the functional impairment, 2 years after cessation of exposure to isocyanates, using the compensation insurance scale proposed in the province of Quebec. Methods: We used a retrospective cohort of 233 patients diagnosed in the province of Quebec between 1985 and 2002 and randomly chose 105 of those… 
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Medical surveillance programme for diisocyanate exposure
TLDR
Subjects with occupational asthma screened by a medical surveillance programme have a better outcome both at the time of diagnosis and 2 years after removal from exposure, with lower compensation costs compared to controls.
Contribution of host factors and workplace exposure to the outcome of occupational asthma
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It is established that older age, high-molecular-weight agents, impaired lung function and longer duration of exposure to the offending agent at the time of diagnosis had a negative role on the outcome of occupational asthma.
Diisocyanate-induced asthma in Switzerland: long-term course and patients’ self-assessment after a 12-year follow-up
TLDR
Significant associations between age, duration of exposure and FEV1/FVC ratio with persistent asthma symptoms and NSBHR are shown, whereas the patients’ self-assessment of their state of health and overall satisfaction improved considerably.
Guidelines for the management of work-related asthma
Work-related asthma, which includes occupational asthma and work-aggravated asthma, has become one of the most prevalent occupational lung diseases. These guidelines aim to upgrade occupational…
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TLDR
SIC appears useful to assess changes in nasal patency after exposure to isocyanate, and can induce nasal congestion that can be objectively monitored during SIC.
Allergens in Occupational Allergy: Prevention and Management – Focus on Asthma
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The main aspects for the prevention and management of occupational asthma due to allergic sensitization in the workplace are reviewed, including an accurate allergen identification and characterization, health surveillance, and management.
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TLDR
Critical analysis of available evidence indicates that persistent exposure to the causal agent is more likely to result in asthma worsening than complete avoidance, and personal respiratory equipment does not provide complete protection.
Quality-of-Life, Psychological, and Cost Outcomes 2 Years After Diagnosis of Occupational Asthma
TLDR
Impaired QOL and PD are frequent among subjects with OA receiving compensation and are associated with clinical markers of OA and socioeconomic factors.
Systematic review of the evidence relating FEV1 decline to giving up smoking
TLDR
It is shown that continuing smokers have a beta that is dose-related and over 10 mL/yr greater than in never smokers, ex-smokers or quitters, and this decline in those with respiratory disease or reduced lung function is consistent with some smokers having a more rapid rate of FEV1 decline.
Comparison of Psychological, Quality of Life, Work-Limitation, and Socioeconomic Status Between Patients With Occupational Asthma and Work-Exacerbated Asthma
TLDR
In a tertiary clinic, there were some modest differences for specific variables between OA and WEA subjects that may help inform management.
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