Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy.

Abstract

BACKGROUND AND PURPOSE CADASIL is an inherited small-vessel disease responsible for lacunar strokes and cognitive impairment. The disease is caused by highly stereotyped mutations in Notch3, the expression of which is highly restricted to vascular smooth muscle cells (VSMCs). The underlying vasculopathy is characterized by degeneration of VSMCs and the… (More)

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