Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation.

@article{Foley2011ImpairedUO,
  title={Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation.},
  author={Stephen F. Foley and Klara Garsed and Gulzar Singh and Nathalie P. Duroudier and Caroline Swan and Ian P Hall and Abed Zaitoun and Andrew Bennett and Charles Alexandar Marsden and Geoffrey Holmes and Andrew Walls and Robin C Spiller},
  journal={Gastroenterology},
  year={2011},
  volume={140 5},
  pages={
          1434-43.e1
        }
}
BACKGROUND & AIMS Patients with irritable bowel syndrome with diarrhea (IBS-D) have increased mucosal serotonin (5-hydroxytryptamine [5-HT]) availability, possibly because immune activation reduces activity of the 5-HT transporter (SERT). We investigated the relationship between mucosal and platelet SERT and immune activation of the duodenal mucosa in patients with IBS-D. METHODS We quantified mucosal intraepithelial lymphocytes (IELs), mast cells, and enterochromaffin cells in blood samples… CONTINUE READING
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