Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression.

@article{BrantleySieders2005ImpairedTM,
  title={Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression.},
  author={Dana M. Brantley-Sieders and Wei Bin Fang and Donna J. Hicks and Guanglei Zhuang and Yu Shyr and Jin Chen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 13},
  pages={1884-6}
}
EphA2 belongs to a unique family of receptor tyrosine kinases that play critical roles in development and disease. Since EphA2 is required for ephrin-A1 ligand-induced vascular remodeling and is overexpressed in a variety of vascularized human adenocarcinomas, we assessed tumor angiogenesis and metastatic progression in EphA2-deficient host animals. 4T1 metastatic mammary adenocarcinoma cells transplanted subcutaneously and orthotopically into EphA2-deficient female mice displayed decreased… CONTINUE READING

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