Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients.

@article{Borger2009ImpairedTO,
  title={Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients.},
  author={Peter Borger and Nicola Miglino and Melissa Baraket and J. L. Black and Michael Tamm and Michael Roth},
  journal={The Journal of allergy and clinical immunology},
  year={2009},
  volume={123 3},
  pages={639-45}
}
BACKGROUND Bronchial smooth muscle (BSM) cells of asthmatic patients have an impaired expression of CCAAT/enhancer binding protein (C/EBP) alpha, which is associated with increased proliferation. OBJECTIVE We sought to assess the translational regulation of CEBPA mRNA in cultured BSM cells of healthy control subjects (n = 11) and asthmatic patients (n = 12). METHODS Translation efficiency was studied by using a translation control reporter system driven by the control elements present in… CONTINUE READING

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