Impaired trace fear conditioning following neonatal ethanol: reversal by choline.

@article{Wagner2006ImpairedTF,
  title={Impaired trace fear conditioning following neonatal ethanol: reversal by choline.},
  author={Alison F Wagner and Pamela S. Hunt},
  journal={Behavioral neuroscience},
  year={2006},
  volume={120 2},
  pages={482-7}
}
Neonatal ethanol exposure in animals results in performance deficits on tests of hippocampus-dependent spatial memory, and recent studies have shown that extra dietary choline can ameliorate some of these impairments. In this experiment, rats were administered 5.25 g/kg ig ethanol per day or sham intubations on Postnatal Days (PD) 4-9 and choline (0.1 ml of an 18.8 mg/ml solution) or saline subcutaneously on PD 4-20. On PD 30, rats were given delay or trace fear conditioning trials and were… CONTINUE READING