Impaired thrombin generation in beta 2-glycoprotein I null mice.

@article{Sheng2001ImpairedTG,
  title={Impaired thrombin generation in beta 2-glycoprotein I null mice.},
  author={Yonghua Sheng and S W Reddel and Herbert Herzog and Yong Xiong Wang and Tim Brighton and Malcolm P. France and Sarah A Robertson and Steven Antony Krilis},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 17},
  pages={13817-21}
}
Autoimmune antibodies to beta(2)-glycoprotein I (beta2GPI) have been proposed to be clinically relevant because of their strong association with thrombosis, miscarriage, and thrombocytopenia. By using a homologous recombination approach, beta2GPI-null mice were generated to begin to understand the physiologic and pathologic role of this prominent plasma protein in mammals. When beta2GPI heterozygotes on a 129/Sv/C57BL/6 mixed genetic background were intercrossed, only 8.9% of the resulting 336… CONTINUE READING
27 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…