Impaired thrombin generation in beta 2-glycoprotein I null mice.

  title={Impaired thrombin generation in beta 2-glycoprotein I null mice.},
  author={Yonghua Sheng and S W Reddel and Herbert Herzog and Yong Xiong Wang and Tim Brighton and Malcolm P. France and Sarah A Robertson and Steven Antony Krilis},
  journal={The Journal of biological chemistry},
  volume={276 17},
Autoimmune antibodies to beta(2)-glycoprotein I (beta2GPI) have been proposed to be clinically relevant because of their strong association with thrombosis, miscarriage, and thrombocytopenia. By using a homologous recombination approach, beta2GPI-null mice were generated to begin to understand the physiologic and pathologic role of this prominent plasma protein in mammals. When beta2GPI heterozygotes on a 129/Sv/C57BL/6 mixed genetic background were intercrossed, only 8.9% of the resulting 336… CONTINUE READING
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