Impaired thermoregulation against cold in capsaicin pretreated rats

@article{Benedek1983ImpairedTA,
  title={Impaired thermoregulation against cold in capsaicin pretreated rats},
  author={Gyorgy Benedek and Margit Szikszay and Ferenc Obál},
  journal={Pfl{\"u}gers Archiv},
  year={1983},
  volume={399},
  pages={243-245}
}
A study was made of the effects of pretreatment with fractionated capsaicin on the changes in body temperature (Tb) induced in rats by exposure to cold and to warm environments, and by administration of histamine (40 mg·kg−1) or of pentobarbital (20 mg·kg−1) At the ambient temperature of 22 °C the Tb of capsaicin pretreated rats was lower than that of rats treated only with solvent (p<0.001). The capsaicin pretreated rats showed impairment of thermoregulation at both high and low environmental… 

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References

SHOWING 1-10 OF 15 REFERENCES

Capsaicin pretreatment interferes with the thermoregulatory effect of morphine

Tail skin vasodilatation and bath test in capsaicin-desensitized rats

It is suggested that capsaicin treatment impaired reflex vasodilatation to heat and the behaviour of using free water for heat dissipation and the performance of desalivated tail-amputated controls remained more tolerant to heat than the desensitized rats.

The effect of ambient temperature on rectal temperature, food intake and short term body weight in the capsaicin desensitized rat

It is concluded that hypothalamic thermodetectors implicated in both thermoregulation and food intake behaviour could be partially damaged by capsaicin.

Salivary cooling, escape reaction and heat pain in capsaicin-desensitized rats

It is suggested that heat perception in desensitized animals is impaired; however, the existence of some capsaicin-insensitive thermolytic mechanisms (prone extension of the body) cannot be excluded.

Shift of threshold temperature for shivering and heat polypnea as a mode of thermal adaptation

This “widening of the interthreshold zone” in CWA-animals is shown to provide a more economical temperature regulation when the animals are subjected to fluctuating environmental conditions, as they are enabled to tolerate body temperature changes to some extent before they actuate their cold or heat defense mechanisms.

Endotoxin fever in capsaicin treated rats.

The fever elicited by 10 micrograms/kg intravenous E. coli endotoxin was significantly higher in capsaicin desensitized rats than in controls, but there was an upper limit to the rise in body

Stimulation and desensitization of the hypothalamic heat‐sensitive structures by capsaicin in rats

1. In rats the injection of capsaicin into the pre‐optic area of the anterior hypothalamus produces a prompt fall in body temperature and abolishes shivering. With repeated injections of capsaicin

Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea‐pigs

1. In rats and guinea‐pigs a subcutaneous or intraperitoneal injection of capsaicin, the substance responsible for the pungency of red pepper, produces profound hypothermia associated with skin