Impaired therapeutic vasculogenesis by transplantation of OxLDL-treated endothelial progenitor cells.

@article{Zhou2007ImpairedTV,
  title={Impaired therapeutic vasculogenesis by transplantation of OxLDL-treated endothelial progenitor cells.},
  author={Bin Zhou and Feng Ma and Peng Xia Liu and Zhi Hong Fang and Si Li Wang and Zhi Bo Han and Man-chiu Poon and Zhong Han},
  journal={Journal of lipid research},
  year={2007},
  volume={48 3},
  pages={518-27}
}
Previous in vitro studies have revealed that oxidized low density lipoprotein (OxLDL) has negative effects on the proliferation and activity of endothelial progenitor cells (EPCs). Here, we evaluated the effect of OxLDL on the therapeutic potential of EPCs in ischemia-induced neovascularization. EPCs derived from mobilized human peripheral blood mononuclear cells were cultured without or with OxLDL before transplantation. Hindlimb ischemia models were surgically induced in athymic nude mice… CONTINUE READING