Impaired testicular cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory (StAR) protein expression in rats with nephrotic syndrome.


Alterations at the pituitary-testicular axis has been already characterized in nephrotic syndrome. Particularly low concentrations of progesterone, testosterone and undetectable levels of estradiol have been associated to the nephrotic condition. Accordingly, to determine if the hormonal withdrawal is the result of steroidogenic failure, we evaluated the… (More)


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