Impaired terminal differentiation of pulmonary macrophages in a Guinea pig model of chronic ethanol ingestion.

@article{Brown2009ImpairedTD,
  title={Impaired terminal differentiation of pulmonary macrophages in a Guinea pig model of chronic ethanol ingestion.},
  author={Sheena D. Brown and Theresa W. Gauthier and Lou Ann Scism Brown},
  journal={Alcoholism, clinical and experimental research},
  year={2009},
  volume={33 10},
  pages={1782-93}
}
BACKGROUND Alcoholic patients have an increased risk of respiratory infections, which is partially due to an impaired immune response of alveolar macrophages. The mechanisms by which alcohol impairs alveolar macrophage function are poorly understood. In this study, we demonstrated in a guinea pig model that chronic ethanol ingestion significantly impaired alveolar macrophage differentiation and function. METHODS Isolated alveolar macrophages were separated into 4 different subpopulations with… CONTINUE READING