Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models

@article{Benyelles2019ImpairedTI,
  title={Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models},
  author={M. Benyelles and H. Episkopou and M. O'Donohue and La{\"e}titia Kermasson and P. Frange and Florian Poulain and Fatma Burcu Belen and M. Polat and C. B{\^o}le-Feysot and Francina Langa-Vives and P. Gleizes and Jean-Pierre de Villartay and I. Callebaut and A. Decottignies and P. Revy},
  journal={EMBO Molecular Medicine},
  year={2019},
  volume={11}
}
PARN, poly(A)‐specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated with Høyeraal–Hreidarsson (HH) syndrome, a rare telomere biology disorder that, because of its severity, is likely not exclusively due to hTR down‐regulation. Whether PARN deficiency was affecting the expression of telomere‐related genes was still unclear. Using cells from two unrelated HH individuals carrying… Expand
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References

SHOWING 1-10 OF 62 REFERENCES
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation.
  • 22
  • Highly Influential
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects
  • 66
  • Highly Influential
Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component
  • 108
  • Highly Influential
  • PDF
Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.
  • 120
  • Highly Influential
  • PDF
Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN)
  • 56
  • Highly Influential
The PARN Deadenylase Targets a Discrete Set of mRNAs for Decay and Regulates Cell Motility in Mouse Myoblasts
  • 50
  • Highly Influential
  • PDF
Destabilization of microRNAs in human cells by 3′ deadenylation mediated by PARN and CUGBP1
  • 56
  • PDF
PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells
  • 36
  • PDF
mRNA deadenylation and telomere disease.
  • 14
  • PDF
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