Impaired systemic cell-mediated immunity and increased susceptibility to acute respiratory tract infections in patients with COPD.

@article{Takabatake2005ImpairedSC,
  title={Impaired systemic cell-mediated immunity and increased susceptibility to acute respiratory tract infections in patients with COPD.},
  author={Noriaki Takabatake and Makoto Sata and Shuichi Abe and Sumito Inoue and Hiroshi Saito and Hideki Yuki and Yoko Shibata and Isao Kubota},
  journal={Respiratory medicine},
  year={2005},
  volume={99 4},
  pages={485-92}
}
Although it has been reported that chronic obstructive pulmonary disease (COPD) is frequently associated with systemic immune disturbances, negative impact of these disturbances on the increased prevalence of acute respiratory tract infections (aRTIs) has remained unclear. We evaluated circulating levels of interferon-gamma (IFN-gamma), soluble interleukin-2 receptor (sIL-2R), neopterin, and soluble intercellular adhesion molecule-1 (sICAM-1) in 35 clinically stable patients with COPD and in 22… CONTINUE READING