Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells.

@article{Maraskovsky1996ImpairedSA,
  title={Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells.},
  author={Eugene Maraskovsky and Mark C. Teepe and Philip J. Morrissey and Sharkeshia Braddy and Robert C. Miller and David H. Lynch and Jacques J. Peschon},
  journal={Journal of immunology},
  year={1996},
  volume={157 12},
  pages={5315-23}
}
Mice genetically deficient in IL-7R(alpha) are highly lymphopenic in the peripheral lymphoid organs. The functional competence of T cells that have developed in the absence of an IL-7R signal was investigated. Three important observations were made using several in vitro activation regimens. First, stimulation of T cells from IL-7R -/- mice at limiting dilution with immobilized Abs to CD3, CD4 or CD8, and CD18 revealed a six- to sevenfold reduction in the frequency of clonogenic T cells… CONTINUE READING

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