Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.

Abstract

Point mutations in the vacuolar protein sorting 35 gene (VPS35) have been associated with an autosomal dominant form of late-onset Parkinson disease (PARK17), but there has been considerable debate over whether it is caused by a loss- or gain-of-function mechanism and over the intracellular target site of neurotoxicity. To investigate the pathogenesis of… (More)
DOI: 10.1093/hmg/ddw279

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