Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.

@article{Tiwari2008ImpairedSE,
  title={Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.},
  author={Swasti Tiwari and Nikhil Sharma and Pritmohinder S. Gill and Peter Igarashi and C Ronald Kahn and James B. Wade and Carolyn M A Ecelbarger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 17},
  pages={
          6469-74
        }
}
Renal tubule epithelial cells express the insulin receptor (IR); however, their value has not been firmly established. We generated mice with renal epithelial cell-specific knockout of the IR by Cre-recombinase-loxP recombination using a kidney-specific (Ksp) cadherin promoter. KO mice expressed significantly lower levels of IR mRNA and protein in kidney cortex (49-56% of the WT) and medulla (32-47%) homogenates. Immunofluorescence showed the greatest relative reduction in the thick ascending… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct.

  • American journal of physiology. Renal physiology
  • 2013
VIEW 9 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

Salt sensitivity of nitric oxide generation and blood pressure in mice with targeted knockout of the insulin receptor from the renal tubule.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2012
VIEW 7 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

Does Thiazolidinedione therapy exacerbate fluid retention in congestive heart failure?

VIEW 15 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Insights from direct renal insulin infusion: a new hammer for an age-old nail.

  • American journal of physiology. Renal physiology
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND