Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice.

@article{Maclean2008ImpairedSM,
  title={Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice.},
  author={Helen E. Maclean and W S Maria Chiu and Amanda J. Notini and Anna-Maree Axell and Rachel A. Davey and Julie F McManus and Cathy A. Malchiodi Ma and David R. Plant and Gordon S Lynch and Jeffrey Zajac},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2008},
  volume={22 8},
  pages={
          2676-89
        }
}
To identify mechanisms of anabolic androgen action in muscle, we generated male and female genomic androgen receptor (AR) knockout (ARKO) mice, and characterized muscle mass, contractile function, and gene expression. Muscle mass is decreased in ARKO males, but normal in ARKO females. The levator ani muscle, which fails to develop in normal females, is also absent in ARKO males. Force production is decreased from fast-twitch ARKO male muscle, and slow-twitch muscle has increased fatigue… CONTINUE READING

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