Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system.

@article{benedetti2006ImpairedSD,
  title={Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system.},
  author={F De benedetti and Nadia Rucci and Andrea Del Fattore and Barbara Peruzzi and Rita Paro and Maurizio Longo and Marina S. Vivarelli and Flaminia Muratori and Silvia Berni and Paola Ballanti and Serge Ferrari and Anna Teti},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 11},
  pages={3551-63}
}
OBJECTIVE To identify the mediator responsible for the impact of chronic inflammation on skeletal development in children (bone loss, defective peak bone mass accrual, stunted growth), we evaluated the effects of chronic interleukin-6 (IL-6) overexpression on the skeletons of growing prepubertal mice. METHODS We studied IL-6-transgenic mice that had high circulating IL-6 levels since birth. Trabecular and cortical bone structure were analyzed by microcomputed tomography. Epiphyseal… CONTINUE READING