Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage.


The impact of prior nasopharyngeal carriage on serotype-specific IgG responses following immunization with pneumococcal conjugate vaccines (PCV) has recently been described. This report extends these findings to describe the attenuation of functional immune responses following 23-valent pneumococcal polysaccharide vaccination (PPS). We report the… (More)
DOI: 10.1016/j.vaccine.2014.02.064