Impaired sequence learning in dystonia mutation carriers: a genotypic effect.

  title={Impaired sequence learning in dystonia mutation carriers: a genotypic effect.},
  author={M. Carbon and Miklos Argyelan and Maria Felice Ghilardi and Paul J. Mattis and Vijay Dhawan and Susan Bressman and David Eidelberg},
  journal={Brain : a journal of neurology},
  volume={134 Pt 5},
Abnormalities in motor sequence learning have been observed in non-manifesting carriers of the DYT1 dystonia mutation. Indeed, motor sequence learning deficits in these subjects have been associated with increased cerebellar activation during task performance. In the current study, we determined whether similar changes are also present in clinically manifesting DYT1 carriers as well as in carriers of other primary dystonia mutations such as DYT6. Additionally, we determined whether sequence… CONTINUE READING
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