Impaired self-other differentiation in frontotemporal dementia due to the C9ORF72 expansion

@inproceedings{Downey2012ImpairedSD,
  title={Impaired self-other differentiation in frontotemporal dementia due to the C9ORF72 expansion},
  author={Laura E. Downey and Colin J. Mahoney and Martin Rossor and Sebastian J. Crutch and Jason D Warren},
  booktitle={Alzheimer's Research & Therapy},
  year={2012}
}
An expanded hexanucleotide repeat in the C9ORF72 gene has recently been identified as an important cause of frontotemporal dementia and motor neuron disease; however, the phenotypic spectrum of this entity and its pathophysiologic basis have yet to be fully defined. Psychiatric features may be early and prominent, although a putative cortico-thalamo-cerebellar network has been implicated in the pathogenesis of the clinical phenotype. Differentiation of self from others is a core cognitive… CONTINUE READING

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