Impaired safety signal learning may be a biomarker of PTSD.

@article{Jovanovic2012ImpairedSS,
  title={Impaired safety signal learning may be a biomarker of PTSD.},
  author={Tanja Jovanovic and Andrew Kazama and Jocelyne Bachevalier and Michael L Davis},
  journal={Neuropharmacology},
  year={2012},
  volume={62 2},
  pages={695-704}
}
A dysregulated fear response is one of the hallmark clinical presentations of patients suffering from posttraumatic stress disorder (PTSD). These patients show over-generalization of fear and in tandem an inability to inhibit fear responses in the presence of safety. Here, we summarize our recent findings using a conditional discrimination paradigm, which assesses safety signal processing (AX+/BX-) in combat and civilian PTSD populations. Overall, PTSD subjects demonstrate a lack of safety… CONTINUE READING

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