Impaired reward processing in the human prefrontal cortex distinguishes between persistent and remittent attention deficit hyperactivity disorder.

@article{Wetterling2015ImpairedRP,
  title={Impaired reward processing in the human prefrontal cortex distinguishes between persistent and remittent attention deficit hyperactivity disorder.},
  author={Friedrich Wetterling and Hazel McCarthy and Leonardo Tozzi and Norbertas Skokauskas and John P. O'Doherty and Aisling Mulligan and James Frances Mary Meaney and Andrew J Fagan and Michael Gill and Thomas Frodl},
  journal={Human brain mapping},
  year={2015},
  volume={36 11},
  pages={4648-63}
}
Symptoms of attention deficit hyperactivity disorder (ADHD) in children often persist into adulthood and can lead to severe antisocial behavior. However, to-date it remains unclear whether neuro-functional abnormalities cause ADHD, which in turn can then provide a marker of persistent ADHD. Using event-related functional magnetic resonance imaging (fMRI), we measured blood oxygenation level dependent (BOLD) signal changes in subjects during a reversal learning task in which choice of the… CONTINUE READING
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