Impaired response to influenza vaccine associated with persistent memory B cell depletion in non-Hodgkin's lymphoma patients treated with rituximab-containing regimens.

@article{Bedognetti2011ImpairedRT,
  title={Impaired response to influenza vaccine associated with persistent memory B cell depletion in non-Hodgkin's lymphoma patients treated with rituximab-containing regimens.},
  author={Davide Bedognetti and Gabriele Zoppoli and Carlotta Massucco and Elisa Zanardi and Simonetta Zupo and Andrea Bruzzone and Mario Roberto Sertoli and Enrico Balleari and Omar Racchi and Marco Messina and Graziano Caltabiano and Giancarlo Icardi and Paolo Durando and Francesco M. Marincola and Francesco M Boccardo and Marina Ferrarini and Filippo Ansaldi and Andrea de Maria},
  journal={Journal of immunology},
  year={2011},
  volume={186 10},
  pages={
          6044-55
        }
}
Influenza vaccination is generally recommended for non-Hodgkin's lymphoma (NHL) patients, but no data are available about the activity of this vaccine after treatment with rituximab-containing regimens. We evaluated the humoral response to the trivalent seasonal influenza vaccine in a group of NHL patients in complete remission for ≥6 mo (median, 29 mo) after treatment with rituximab-containing regimens (n = 31) compared with age-matched healthy subjects (n = 34). B cell populations and… CONTINUE READING

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