Impaired resistance artery function in patients with end-stage renal disease.

@article{Luksha2011ImpairedRA,
  title={Impaired resistance artery function in patients with end-stage renal disease.},
  author={Natallia Luksha and Leanid Luksha and Juan Jes{\'u}s Carrero and Folke Hammarqvist and Peter Stenvinkel and Karolina R. Kublickiene},
  journal={Clinical science},
  year={2011},
  volume={120 12},
  pages={
          525-36
        }
}
We investigated an effect of uraemia on structural and functional features of human resistance vasculature. Arteries (≈ 200 μm) isolated from subcutaneous fat biopsies obtained from 35 ESRD (end-stage renal disease) patients starting peritoneal dialysis and 30 matched controls were studied using isolated small artery bioassays. Flow-mediated dilatation was attenuated in ESRD patients compared with controls. NO (nitric oxide) contribution to flow was lacking in ESRD patients, but present in the… CONTINUE READING

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